
Risks to human health, through the food chain and drinking water, from the pathogens, antibiotics and hormonal substances that may be present in organic amendments can be reduced by treatment before land application, such as in the case of sewage biosolids. covered liquid or slurry storage, rapid incorporation into the soil, timing applications to minimize delay before plant uptake) also tend to favor survival of pathogens.

Some approaches aimed at limiting N losses (e.g. Antibiotics, other pharmaceuticals and naturally produced hormones may pose a threat if they increase the number of zoonotic disease organisms that are resistant to multiple antimicrobial drugs or interfere with reproductive processes. Animal manure and sewage biosolids, the organic amendments in greatest abundance, contain components that can be hazardous to human health, other animals and plants. Challenges from the use of organic amendments arise from the presence of heavy metals and the inability to control the transformations required to convert the organic forms of N and P into the minerals available to crops, and particularly to minimize the losses of these nutrients in forms that may present a threat to human health.

Organic amendments provide macro- and micronutrients, including carbon for the restoration of soil physical and chemical properties. Their use allows better management of often-finite resources to counter changes in soils that result from essential practices for crop production. Historically, organic amendments-organic wastes-have been the main source of plant nutrients, especially N.
